Molecular Hydrogen overcome side-effects of radiation for cancer therapy.
Cancer is normally treated with radiation, however the side-effects from radiation makes managing and treating cancer even more difficult.
Medical studies and scientific research have indicated that consumption of molecular hydrogen and specifically Hydrogen Water can provide a better quality-of-life for people who are being treated with radiation, without diminishing the effectiveness of radiation against cancerous cells.
This medical research is creating new interest in cancer treatment because there are currently few methods available to address the side-effects of radiation, and many of these treatments are not completely safe instead causes other complications.
Molecular hydrogen is also commonly known as hydrogen gas. One common method for consuming molecular hydrogen is the infusion of hydrogen gas in ionized purified water. The FDA has recently issued a notice that molecular hydrogen is generally regarded as safe to be formulated in beverages.
Radiation is a common method to treat cancer and address its symptoms. Unfortunately, exposure to radiation can produce side-effects that are difficult to manage. Listed below are a summary of the common side-effects of radiation exposure and potential benefits of molecular hydrogen:
A 2012 clinical study, published in part by the University of Pittsburgh (Pittsburgh, USA), provided the first evidence that Molecular Hydrogen protects humans from the side-effects of radiation exposure. This clinical trial demonstrated that Molecular Hydrogen improved the quality-of-life of patients who received radiation to treat their cancer diagnosis. Molecular Hydrogen led to a significantly better appetite and fewer tasting disorders. These benefits were provided with no side-effects from Molecular Hydrogen, which did not interfere with the effectiveness of radiation on tumours.
Science is a well-renowned journal that announced the discovery that consumption of molecular hydrogen led to the regression of cancer that was caused by radiation. Baylor University (Waco, TX) conducted the study. In this scientific article, American researcher Dr. Malcom Dole was the first individual to clearly demonstrate that health benefits are provided with consumption of molecular hydrogen. After providing molecular hydrogen to mice that had skin cancer, Dr. Dole demonstrated that molecular hydrogen led to the regression of tumours.
Radiation can cause cardiac disease and chronically impair functions of the heart. In 2010, a research study indicated Molecular Hydrogen prevented scarring (fibrosis) of hearts in mice that received radiation. Fibrosis is formed in many tissues (etc., skin, lung and liver) after radiation exposure and can cause these tissues to be less functional.
While radiation can be used as a treatment for some cancers, radiation is a well known cause of other cancers and can promote the progression of cancer to a more aggressive disease. A key research paper has provided evidence that molecular hydrogen lowered the rate of cancer (thyme lymphomas) and increased the latency of these cancers that occur from radiation exposure.
One of the serious issues regarding radiation therapy is that these treatments can lead to a reduction in cells and affect the functions of organs which are important for our immunity. A common cause of death from radiation is infection within the blood stream. As one of the most important immune organs, impairment of the spleen can lead to increased risk of infection, impaired wound healing and persistent inflammation. In 2014, scientific researchers studying a mouse-model for radiation exposure reported that molecular hydrogen protected the size and function of the spleen and, while reducing inflammatory agents, prevented the massive killing of white blood cells such as lymphocytes and even restored the proliferation of blood cells. It is important to note that the thymus and gut are additional sources of immunity for the body. Scientific research has also indicated that molecular water protected the viability of the thymus and prevented a decrease in white blood cells and platelets, in addition to the evidence that molecular hydrogen protected intestinal tissue, in mice that received radiation.
The lung is highly sensitive to radiation. Radiation can damage the lung directly after exposure and lead to a loss of pulmonary function from fibrosis that develops months or even years after radiation exposure. A published study has demonstrated that molecular hydrogen protected the lungs in mice that received radiation, including the ability of hydrogen gas to immediately prevent cell death and thereafter reduce the risk of developing fibrosis.
Radiation can result in temporary or permanent infertility to man. The testis is appreciably sensitive to radiation because of the presence of rapidly, proliferating cells. It has been shown that molecular hydrogen can protect the size of the testis and sperm viability, quantity and motility while restoring testosterone levels.
Skin infections, such as erythema, swelling, blisters and ulceration, followed by development of chronic inflammation, necrosis, fibrosis and lymphedema are common-side-effects of radiation exposure. Radiation-induced ulcers are often chronic and poor healing with a high relapse rate, and are commonly intractable. Studies have shown that molecular hydrogen accelerated wound healing and reduced inflammation of skin that was exposed to radiation.
Radiation can affect healthy brain cells. Dead or injured brain cells take up space and induce swelling, which can cause poor appetite, sleepiness, lack of energy, problems thinking clearly, difficulty managing tasks that were once easy, poor memory, confusion, personality changes, headaches and a worsening of old symptoms. Studies indicates that molecular hydrogen protected against oxidation and cell death of nerve cells in brains of mice that were exposed to radiation.
Molecular hydrogen has been shown to improves quality-of-life for people who are being treated with radiation, without diminishing the effectiveness of radiation against cancerous cells.
Numerous studies have indicated publications the many health benefits of molecular hydrogen. Molecular hydrogen is natural, safer and effective protective agent as compared to traditional treatments for radiation exposure. Medical studies and scientific research have indicated that molecular hydrogen protected against and reversed the side-effects of a single dose or multiple doses of radiation. Moreover, molecular hydrogen has been shown to reduce radiation injury to a variety of biological tissues and organs including the gut, bone marrow, testis, skin, lung, cardiovascular system, heart and brain.
Question: If Molecular Hydrogen increases the viability of normal cells, does Molecular Hydrogen reduce the effectiveness of radiation on killing cancerous cells? Fact: Studies indicate that Molecular Hydrogen is not associated with any side-effects nor does molecular hydrogen decrease the medical benefits of radiation on cancers. Therefore, molecular hydrogen can address side-effects of radiation without reducing the anti-tumor effects.
Question: Is molecular hydrogen natural for the body? Fact: The body naturally produces molecular hydrogen from prokaryotic cells that symbiotically reside in humans. Our blood circulates this molecular hydrogen and transports the hydrogen gas into tissues and organs, and ultimately into every cell.
Chuai, Y., Gao, F., Li, B., Zhao, L., Qian, L., Cao, F., … Cai, J. (2012). Hydrogen-rich saline attenuates radiation-induced male germ cell loss in mice through reducing hydroxyl radicals. The Biochemical Journal, 442(1), 49–56. http://doi.org/10.1042/BJ20111786
Chuai, Y., Qian, L., Sun, X., & Cai, J. (2012). Molecular hydrogen and radiation protection. Free Radical Research, 46(9), 1061–7. http://doi.org/10.3109/10715762.2012.689429
Chuai, Y., Shen, J., Qian, L., Wang, Y., Huang, Y., Gao, F., … Cai, J. (2012). Hydrogen-rich saline protects spermatogenesis and hematopoiesis in irradiated BALB/c mice. Medical Science Monitor?: International Medical Journal of Experimental and Clinical Research, 18(3), BR89–94. Retrieved from http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3560739&tool=pmcentrez&rendertype=abstract
Chuai, Y., Zhao, L., Ni, J., Sun, D., Cui, J., Li, B., … Cai, J. (2011). A possible prevention strategy of radiation pneumonitis: combine radiotherapy with aerosol inhalation of hydrogen-rich solution. Medical Science Monitor?: International Medical Journal of Experimental and Clinical Research, 17(4), HY1–4. Retrieved from http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3539519&tool=pmcentrez&rendertype=abstract
Dole, M., Wilson, F. R., & Fife, W. P. (1975). Hyperbaric hydrogen therapy: a possible treatment for cancer. Science (New York, N.Y.), 190(4210), 152–4. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/1166304
Hongmei, H., Shun, Y., Liesong, C., Haijun, L., Aidong, W., & Liyuan, Z. (2012). Hydrogen-rich saline alleviation on the oxidative stress and early-phase radiation-induced brain injury in rats. Retrieved from http://inis.iaea.org/Search/search.aspx?orig_q=RN:46111388
Jiang, Z., Xu, B., Yang, M., Li, Z., Zhang, Y., & Jiang, D. (2013). Protection by hydrogen against gamma ray-induced testicular damage in rats. Basic & Clinical Pharmacology & Toxicology, 112(3), 186–91. http://doi.org/10.1111/bcpt.12016
Kang, K.-M., Kang, Y.-N., Choi, I.-B., Gu, Y., Kawamura, T., Toyoda, Y., & Nakao, A. (2011). Effects of drinking hydrogen-rich water on the quality of life of patients treated with radiotherapy for liver tumors. Medical Gas Research, 1(1), 11. http://doi.org/10.1186/2045-9912-1-11
Liu, C., Cui, J., Sun, Q., & Cai, J. (2010). Hydrogen therapy may be an effective and specific novel treatment for acute radiation syndrome. Medical Hypotheses, 74(1), 145–6. http://doi.org/10.1016/j.mehy.2009.07.017
Mei, K., Zhao, S., Qian, L., Li, B., Ni, J., & Cai, J. (2014). Hydrogen protects rats from dermatitis caused by local radiation. The Journal of Dermatological Treatment, 25(2), 182–8. http://doi.org/10.3109/09546634.2012.762639
Ohsawa, I., Ishikawa, M., Takahashi, K., Watanabe, M., Nishimaki, K., Yamagata, K., … Ohta, S. (2007). Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals. Nature Medicine, 13(6), 688–94. http://doi.org/10.1038/nm1577
The Fight against Free Radicals
Hydrogen Molecules acting as strong antioxidants fights free radicals that slowly destroy your cell. These dangerous free radicals multiply by chain reaction, breaking up stable molecules in our cell and forming more free radicals. The continuous destruction of our cell molecules by these free radicals greatly affected their cellular function which finally lead to the breakdown of the cell DNA and destruction of the blood protein. These relentless attack finally caused total breakdown of the cellular function in the affected area and this lead to cancer.
Hydrogen therapy attenuates irradiation-induced lung damage by reducing oxidative stress
Before a bone marrow transplant, cancer patients often undergo total body irradiation (TBI) in order to prevent their immune system from rejecting the transplanted tissue. This irradiation can create reactive oxygen species (ROS) in the body, which can damage DNA and often causes injury to the lungs.
The scientists from Nippon Medical School in Japan studied whether hydrogen could protect the lungs from irradiation injury. There were two parts to this study. 1) They did in vitro (test tube) testing on cultured lung cells to learn about the molecular mechanism of how hydrogen works as an ROS scavenger. 2) They exposed mice to irradiation while treating them with hydrogen gas to breath and hydrogen rich water to drink.
The in vitro study showed that hydrogen reduced hydroxyl radicals and protected the cells from the damage of oxidative stress caused by irradiation. This finding substantiated other studies, which have shown that hydrogen works as an antioxidant. In the irradiated mice, it was found that hydrogen treatment reduced oxidative stress and suppressed both acute lung injury and long-term fibrosis of the lungs.
Effects of drinking hydrogen-rich water on the quality of life of patients treated with radiotherapy for liver tumors
Cancer patients receiving radiation therapy often experience fatigue and impaired quality of life. Scientists gave hydrogen-rich water to human patients who were receiving radiation therapy for liver tumors. The patients drank 1.5 to 2 liters of hydrogen-rich water each day for 6 weeks. Another group of patients also receiving radiation therapy for liver tumors were given regular water to drink (this is called a placebo). Results reported in this study were:
Hydrogen water improved the quality of life of patients receiving radiotherapy
Hydrogen water mitigated oxidative stress marker during radiotherapy
Hydrogen water did not compromise the radiation treatment efficacies
Hydrogen treatment did not alter liver function or blood composition during radiotherapy
The production of ROS by human cancer cells is higher than that for normal cell lines (73). In addition, elevated levels of ROS appear to play a role in the signaling cascades that trigger and maintain the oncogenic phenotype of cancer cells (74), and may contribute to DNA damage, and cell proliferation, migration and survival (75). Therefore, the possible anticancer effects of hydrogen, alone or in combination with traditional therapy, are the subject of growing research (76).
In an in vitro study, hydrogen-enriched water (1.0–1.3 ppm) supplemented with platinum nanocolloid showed rapid antioxidant effects and preferentially inhibited clonal growth of human tongue carcinoma cells compared with normal cells (77). Hydrogen-enriched water has also been shown to increase the inhibitory effects of the chemotherapy agent fluorouracil on colon cancer cells (76). In a mouse model of colon cancer, hydrogen-enriched water (≈0.8 mM) significantly increased survival compared with placebo water treatment, and survival was increased to an even greater extent when hydrogen-enriched water was combined with fluouracil (76).
Radiotherapy is associated with radiolysis of H2O to •OH, which contributes to a range of adverse effects (33). The results of one preclinical study showed that hydrogen-enriched saline (>0.6 mM) protects cells against radiation-induced toxicity and ameliorates intestinal injury caused by radiation (78). Another showed that hydrogen-enriched saline (>0.6 mM) markedly reduced ROS levels after radiation and protected against radiation-induced immune dysfunction (79), while a third indicated that treatment with hydrogen-enriched saline (0.6 mM) before ionizing radiation could provide partial protection of both spermatogenesis and hematopoiesis (80). Hydrogen has been proposed as a possible preventive strategy for radiation pneumonitis because of its ability to quickly scavenge free radicals produced by irradiation of the lungs (81).
The effects of drinking hydrogen-enriched water were investigated in a randomized, placebo-controlled study of patients receiving radiotherapy for liver tumors (82). Treatment with 1.5–2L hydrogen-enriched (0.55–0.65 mM) or placebo water was started on the first day of radiation treatment and continued for 6 weeks. Drinking hydrogen-enriched water prevented the marked increase in total serum hydroperoxide associated with radiotherapy, and attenuated the radiation-related reduction in serum antioxidant activity. Patients in the hydrogen-enriched water group reported significantly less loss of appetite and fewer taste disorders compared with those receiving placebo. Importantly, hydrogen-enriched water had no effect on the efficacy of radiotherapy (82).
Side effects of cisplatin
Based on the results of an in vivo study, hydrogen also has the potential to alleviate chemotherapy-associated toxicity. Two administration routes (oral hydrogen-enriched drinking water [0.8 mM] and inhaled hydrogen [1%]) were assessed in mice receiving cisplatin (83). Both forms of hydrogen improved survival, reduced body weight loss and ameliorated cisplatin-induced nephrotoxicity compared with control, although the effects of drinking hydrogen-enriched water appeared to be less than those of inhaled hydrogen with respect to prevention of severe nephrotoxicity. The anti-tumor efficacy of cisplatin was unaffected by concomitant administration of hydrogen by either route (83).
Effects of drinking hydrogen-rich water on the quality of life of patients treated with radiotherapy for liver tumors.
Cancer patients receiving radiotherapy often experience fatigue and impaired quality of life (QOL). Many side effects of radiotherapy are believed to be associated with increased oxidative stress and inflammation due to the generation of reactive oxygen species during radiotherapy. Hydrogen can be administered as a therapeutic medical gas, has antioxidant properties, and reduces inflammation in tissues. This study examined whether hydrogen treatment, in the form of hydrogen-supplemented water, improved QOL in patients receiving radiotherapy.
A randomized, placebo-controlled study was performed to evaluate the effects of drinking hydrogen-rich water on 49 patients receiving radiotherapy for malignant liver tumors. Hydrogen-rich water was produced by placing a metallic magnesium stick into drinking water (final hydrogen concentration; 0.55~0.65 mM). The Korean version of the European Organization for Research and Treatment of Cancer’s QLQ-C30 instrument was used to evaluate global health status and QOL. The concentration of derivatives of reactive oxidative metabolites and biological antioxidant power in the peripheral blood were assessed.
The consumption of hydrogen-rich water for 6 weeks reduced reactive oxygen metabolites in the blood and maintained blood oxidation potential. QOL scores during radiotherapy were significantly improved in patients treated with hydrogen-rich water compared to patients receiving placebo water. There was no difference in tumor response to radiotherapy between the two groups.
Daily consumption of hydrogen-rich water is a potentially novel, therapeutic strategy for improving QOL after radiation exposure. Consumption of hydrogen-rich water reduces the biological reaction to radiation-induced oxidative stress without compromising anti-tumor effects.
More related studies :
1.Akio Kagawa, K.K., Masayuki Mizumoto, Yutaka Tagawa, Yoichi Masiko, Influence of Hydrogen Discharged from Palladium Base Hydrogen Storage Alloys on Cancer Cells. Materials Science Forum, 2012. 706: p. 520-525.
2 .Asada, R., et al., Antitumor effects of nano-bubble hydrogen-dissolved water are enhanced by coexistent platinum colloid and the combined hyperthermia with apoptosis-like cell death. Oncol Rep, 2010. 24(6): p. 1463-70.