What is molecular hydrogen (H2)?

Our bodies are constantly been attacked by toxic free radicals (unstable molecules with unpaired electrons) formed through the molecular process of oxidation. We are also exposed to these damaging free radicals through a variety of external factors including: exposure to UV radiation, air pollution, toxins, sleep deprivation, stress, cigarette smoke, electromagnetic fields from electronic devices, poor nutrition, exercise, and more. In an attempt to neutralize themselves, these destructive free radicals attack the nearest stable molecule and “steal” its electron. As a result, the “attacked” molecule turns into a free radical and sets off a chain reaction throughout the body. 


Although our body is typically equipped to handle free radicals to a certain extent, excessive amounts and the lack of proper antioxidants within the body will lead to seriously damaging consequences, including: oxidative stress, chronic inflammation throughout the body, joint pain, neurodegenerative disease and premature aging. Moreover, free radical damage and inflammation are at the root of chronic diseases such as cancer, heart disease, diabetes, and more.


Fortunately, our body has a way to wage war on these free radicals: antioxidants. As our body’s first line of defense, these powerful molecules work to prevent or slow down the damage to our cells by stopping free radicals in their tracks. However, not all antioxidants are effective, and many studies have shown that supplemental antioxidants can even be seriously damaging and further exacerbate the risk of disease.


So how can Molecular Hydrogen (H2) play a role ?

Molecular hydrogen (H2) is a gas consisting of two bonded hydrogen atoms. As one of the building blocks of life, hydrogen is one of the oldest, simplest and most abundant molecules in the universe. As the smallest and lightest molecule on earth, the hydrogen atom contains one proton and one electron.

Referred to as “the real fountain of youth,” the most current and credible bodies of research have deemed molecular hydrogen to be the most potent and powerful antioxidant in existence. At a standard temperature and pressure, H2 is colorless, odorless, flavorless, and non-toxic. At low concentrations (typically infused in water), this powerful molecule has repeatedly shown to exhibit tremendously significant therapeutic health benefits and, more importantly, has absolutely no side effects.

 

Why is Hydrogen Molecules (H2) so special and powerful?

Hydrogen can rapidly diffuse deep into all the cells and mitochondria, as well as easily pass through the blood brain barrier. This gives it a higher cellular bioavailability above any other supplement, drug or nutraceutical.

Bioavailable
As the lightest element on earth, H2 is the ONLY antioxidant that has the power to readily and efficiently enter cells, scavenging free radicals inside the nucleus and mitochondria.

Selective
While an excess of free radicals can be extremely damaging for our health, a select group of them are shown to have various beneficial properties. Furthermore, H2 is selective, and ONLY scavenges and neutralizes the most damaging harmful free radicals, leaving the beneficial ones alone.

Clean
While many antioxidant products leave behind toxic byproducts, the only byproduct of H2 is water.

Balanced
The majority of available antioxidants are only effective at high doses, resulting in dangerous and potentially detrimental imbalances within our bodies. In contrast, not only is it impossible to take “too much” H2 (as any surplus is naturally expelled through the lungs), but by bringing the body to a state of equilibrium, it facilitates and helps our bodies reach and maintain an optimum level of health.

Supportive
In addition to acting as the most powerful antioxidant, H2 also helps our bodies naturally produce other antioxidants and improves cell signaling, cell metabolism, and gene expression giving it anti-inflammatory, anti-allergy, anti-apoptotic (anti-cell death), and anti-obesity effects.

Natural
The human body is perfectly primed to accept molecular hydrogen as a beneficial substance. In fact, diets rich in fiber naturally produce H2 in the digestive tract.

Convenient
The simple and practical methods of administration (either via drinking H2 infused water or breathing H2 infused air) make it easy to implement into any daily regimen, from any place in the world.

Studied
The peer-reviewed scientific evidence is mounting with over 850 studies – H2 has powerful therapeutic potential for a multitude of disease models, and more studies are currently ongoing.

Safe
There are no toxic byproducts of H2 therapy, no negative side effects, and no way to take too much. Any excess H2 is simply expelled through the lungs.

New
This is truly a groundbreaking concept in health. The studies on molecular hydrogen truely began in 2007, and since then about 600 related studies had been carried out with very positive results. The great interest in hydrogen therapeutic effect had started the Hydrogen Evolution in bringing HEALTH, BEAUTY AND VITALITY to all human beings.

How is Hydrogen Molecules (H2) so powerful?

Molecular hydrogen works in 3 distinct ways:

​1.   H2 is a unique antioxidant in that it is selective, scavenging only the most toxic and damaging free radicals (sources of inflammation, DNA damage, and chronic disease) while avoiding those which are essential in cell signaling (the communication between cells) and proper immune functioning.Thus, H2 effectively works to reduce excessive oxidative stress ONLY under conditions leading to the destruction and damage of our cells. Additionally, as the smallest molecule in the universe, H2 can easily penetrate any cell membrane, including brain cells, neutralizing certain intracellular free radicals that other antioxidants are unable to reach.

​2.   H2 helps the body trigger its own antioxidant and cell-protective chemicals, naturally boosting the immune system. For example, H2 activates the NRF2 pathway, the body’s own self-defense system against free radicals, but only when there is an assault (such as a toxin or an injury). In turn, by modulating the expression of antioxidant proteins, H2 naturally boosts the body’s immune system, consequently preventing the onset of numerous diseases and conditions.

H2 also has the capacity to reduce the formation of free radicals by down-regulating the NADPH oxidase system (a system responsible for generating the reactive oxygen species (ROS).

3.   H2 helps to improve cell signaling (the communication between cells), which has beneficial metabolic, anti-inflammatory, and anti-cell death properties. While the exact mechanisms behind these processes require further research, H2 has been shown to successfully regulate the expression of over 200 biomolecules, including over 1,000 variations of gene expression. For example, H2 has been shown to down-regulate the expression of pro-inflammatory cytokines, which are involved with promoting systemic inflammation.

Molecular Hydrogen Foundation’s Tyler LeBaron
discusses the benefits of Molecular hydrogen

 

Hydrogen Rich Water is a super anti-oxidant:

Stop the damaging chain reaction of free-radicals in your body.Eliminating free-radicals and reducing the oxidative stress  on your DNA and immune system.
Helps your body to fight against aging and disease. H2 is the smallest antioxidant in existence. Other antioxidants such as Vitamin C or Vitamin E are very large molecules compared to H2 and need to go through your digestive tract, absorbed in your intestines, go through your blood, and enter into your cells before they can eliminate free radicals. H2 is so small that it can penetrate through your stomach lining to begin neutralizing free radicals in almost all our body organs.

The New Antioxidant

By Ianbh  |  Posted October 7, 2014

 

Hydrogen rich water for the prevention and treatment of a variety of diseases—particularly those associated with ROS (reactive oxygen species) and inflammation—has certainly become a hot research subject.

400+ reports in peer-reviewed scientific and medical journals, including in vitro and animal studies, plus some clinical trials in humans, have already been published.

Diseases that may be beneficially affected by hydrogen therapy include, (to name a few), atherosclerosis, ischemia-reperfusion injury (as occurs in heart attacks and strokes), diabetes, stress-induced cognitive impairments, Parkinson’s disease (as shown in animal models), and various aspects of the metabolic syndrome (e.g., insulin sensitivity, glucose tolerance, and endothelial function).

As reported in an excellent review on the “recent progress toward hydrogen medicine,” the author describes various methods being used in published animal and human studies to administer hydrogen: inhalation of hydrogen gas, oral ingestion by drinking hydrogen water, hydrogen baths (because hydrogen easily penetrates the skin and distributes throughout the body via blood flow), injection of hydrogen saline, direct absorption of hydrogen (as in hydrogen containing eye drops), and increased production of hydrogen by gut bacteria.

One reason for the use of hydrogen water and hydrogen saline is that it is possible to reliably control the dose administered to experimental animals, which is important in determining results such as dose-response relationships. In the case of gut bacteria-provided hydrogen, it is less easy to determine the hydrogen “dose,” although one way to at least partially overcome this problem is to measure the hydrogen gas excreted by the lungs.

The conclusion of the Studies: Hydrogen Is a Selective Antioxidant, Scavenging Dangerous Radicals But Not Radicals Important as Physiological Signaling Molecules

Hydrogen and carbon dioxide, as well as (in some people) methane, are gases released by colonic bacteria in the fermentation by the bacteria of carbohydrates that reach the lower digestive tract. Hydrogen has been known to have antioxidant properties for a long time, but its recognition as having some advantages over conventional antioxidants and its potential use as a therapeutic agent have only recently been explored.

One of the most interesting findings concerning hydrogen as an antioxidant is the discovery that it is a novel antioxidant because it scavenges the toxic hydroxyl radical (the strongest of the oxidant species) and the potent oxidant peroxynitrite (formed by the reaction of superoxide and nitric oxide), but is far less effective in scavenging physiological radicals such as superoxide and nitric oxide, important (at low concentrations) as signaling molecules.

Moreover, hydrogen is able to diffuse extremely rapidly into tissue and “effectively reaches the nucleus and mitochondria,”1suggesting “preventive effects on lifestyle-related diseases, cancer, and the aging process.” Hydrogen also passes through the blood-brain barrier, although most antioxidant compounds cannot do this.

References

  1. Ohta. Recent progress toward hydrogen medicine: potential of molecular hydrogen for preventive and therapeutic applications. Curr Pharm Des 17:2241-52 (2011).
    2. Hong et al. Hydrogen as a selective antioxidant: a review of clinical and experimental studies. J Int Med Res 38:1893-1903 (2010).
    2a. Kaur et al. In vitro batch fecal fermentation comparison of gas and short-chain fatty acid production using “slowly fermentable” dietary fibers. J Food Sci 76(5):H137-42 (2011).
    2b. Ito et al. Degree of polymerization of inulin-type fructans differentially affects number of lactic acid bacteria, intestinal immune functions, and immunoglobulin A secretion in the rat cecum. J Agric Food Chem 59:5771-8 (2011).
    2c. Ohsawa et al. Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals, Nat Med 13(6):688-94 (2007).